Yazar "Atalar, Fatmahan" için listeleme
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11β HSD-1 and PAI-1 gene expression fructose induced metabolic syndrome rats
Akan, Gökçe; İnan, Öznur; Atalar, Fatmahan; Görmüş, Uzay; Bilir, Ayhan; Özdilli, Kürşat; Altuğ, Tuncay (2013)Backround: Metabolic syndrome (MetS) is an important health issue worldwide. It is a prevalent and complex disease, characterized by the variable coexistence of obesity, dyslipidemia, hyperinsulinaemia, and hypertension. ... -
11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease
Atalar, Fatmahan; Vural, Burçak; Çiftci, Çavlan; Demirkan, Ayşe; Akan, Gökçe; Süsleyici-Duman, Belgin; Büyükdevrim, Ahmet Sevim (Genetics and Molecular Research, 2012)11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) activity and mRNA levels are increased in visceral and subcutaneous adipose tissues of metabolic syndrome subjects. We analyzed 11β-HSD-1 expression in human epicardial ... -
Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-alpha and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease
Gormez, Selcuk; Demirkan, Ayse; Atalar, Fatmahan; Caynak, Baris; Erdim, Refik; Sozer, Volkan; Buyukdevrim, Ahmet Sevim (JAPAN SOC INTERNAL MEDICINE, 2011)Objective Metabolic syndrome (MS) is associated with an increased risk of coronary artery disease (CAD) and type 2 diabetes mellitus (DM). In MS, adipose tissue has been shown to function as a paracrine and an endocrine ... -
Association study of the DIO2 gene as a susceptibility candidate for schizophrenia in the Turkish population; A case-control study
Colak, A; Akan, Gökçe; Oncu, F; Yanbay, H; Acar, S; Yesilbursa, D; Atalar, Fatmahan (Elsevier, 2013)Introduction: Schizophrenia (SCH) is one of the major and potentially severe mental illness that is characterized by both genetic and clinical heterogeneity. Thyroid hormone plays an important role in the development of ... -
Cardiac visceral and subcutaneous adipose tissue adipokines are dysregulated in obesity and coronary artery disease
Atalar, Fatmahan; Görmez, Selçuk; Çaynak, Barış; Akan, Gökçe; Akpınar, Belhhan; Günay, Demet; Yazıcı, Zeliha (13.Ulusal Tıbbi Biyoloji ve Genetik Kongresi, 27-30 Ekim 2013, 2013)BACKGROUND: Coronary heart disease is one of the most common type of heart disease and the leading cause of mortality worldwide. A close association between obesity and increased cardiovascular diseases has been established ... -
herg1b Expression as a Potential Specific Marker in Pediatric Acute Myeloid Leukemia Patients with HERG 897K/K Genotype
Erdem, Merve; Tekiner, Tugce Ayca; Fejzullahu, Arta; Akan, Gokce; Anak, Sema; Saribeyoglu, Ebru Tugrul; Atalar, Fatmahan (TAYLOR & FRANCIS INC, 2015)Human ether-a-go-go related gene (herg) encoding HERG K+ channel has been demonstrated in many previous studies with its association to cell cycle progression and growth in tumor cells. The upregulated expression of HERG ... -
Mediastinal adipose tissue expresses a pathogenic profile of 11 beta-hydroxysteroid dehydrogenase Type 1, glucocorticoid receptor, and CD68 in patients with coronary artery disease
Atalar, Fatmahan; Gormez, Selcuk; Caynak, Baris; Akan, Gokce; Tanriverdi, Gamze; Bilgic-Gazioglu, Sema; Yazici, Zeliha (ELSEVIER SCIENCE INC, 2013)Objective: Cardiac visceral fat is accepted to be a new marker for cardiometabolic risk due to its association with increased cardiovascular risk factors. This study aimed to compare the expression of 11 beta hydroxysteroid ... -
OPN gene polymorphism (Ala250) and lower serum OPN levels are associated with urolithiasis
Tugcu, Volkan; Simsek, Abdulmuttalip; Tarhan, Tugba; Atalar, Fatmahan; Bitkin, Alper; Tasci, Ali Ihsan; Altug, Tuncay (TAYLOR & FRANCIS LTD, 2013)Osteopontin (OPN) is one of the urinary proteins with an important role in stone formation. Recently, OPN Ala250 (rs1126616) polymorphism and other single nucleotide polymorphisms (SNPs) have been studied to define their ... -
Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome
Vural, Burçak; Atalar, Fatmahan; Çiftçi, Çavlan; Demirkan, Ayşe; Süsleyici-Duman, Belgin; Günay, Demet; Büyükdevrim, Ahmet Sevim (Elsevier, 2008)Background: Metabolic syndrome is a cluster of different clinical manifestations that are risk factors for atherothrombotic cardiovascular disorders. Fatty-acid-binding protein 4 (FABP4/aP2), which is highly expressed in ... -
Relationships between visceral/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome
Gormez, Selcuk; Erdim, Refik; Akan, Gokce; Caynak, Baris; Duran, Cihan; Gunay, Demet; Atalar, Fatmahan (Elsevier Science Inc, 2020)Background: Cytoplasmic fatty acid-binding proteins facilitate the transport of lipids to specific compartments in cells. Fatty acid-binding protein 4 (FABP4), also known as aP2 or A-FABP, plays a key role in the development ... -
The role of mediastinal adipose tissue 11 beta-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease
Atalar, Fatmahan; Gormez, Selcuk; Caynak, Baris; Akan, Gokce; Tanriverdi, Gamze; Bilgic-Gazioglu, Sema; Yazici, Zeliha (BMC, 2012)Background: Visceral fat deposition and its associated atherogenic complications are mediated by glucocorticoids. Cardiac visceral fat comprises mediastinal adipose tissue (MAT) and epicardial adipose tissue (EAT), and MAT ... -
Yüksek fruktoz diyet ile metabolik sendrom oluşturulan sıçanlarda omental yağ dokusunda glukokortikoid etkinliği ve buna bağlı olarak artan PAI-1 gen ekspresyonu
Akan, Gökçe; İnan, Öznur; Atalar, Fatmahan; Görmüş, Uzay; Bilir, Ayhan; Çiftçi, Çavlan; Altuğ, Tuncay (2013)Giriş: Metabolik sendrom (MetS) başta gelişmiş ülkeler olmak üzere tüm dünyada prevalansı giderek artan bir sağlık sorunudur. Son yıllardaki çalışmalar yüksek fruktoz tüketiminin MetS gelişiminde önemli faktörlerden biri ...